Because synapses are responsible for passing information between neurons, these connections are vital for communication within and outside the brain. Therefore, understanding how they form, function, ...

Clinical portfolio, informed by deep and novel synapse biology and pharmacology insights, aims to strengthen neural connections through event-driven pharmacology Lead candidate zelquistinel is ...

Scientists have uncovered how a protein helps build and maintain vital brain connections, providing insights into the neurological problems experienced by people with a rare form of muscular dystrophy ...

The ability to regrow lost synapses can be life changing; for Derek Small, cofounder and CEO of the start-up Syndeio Biosciences, it holds personal relevance. Around a decade ago, Small watched his ...

The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a paper in Nature Communications that determined that liquid-liquid phase separation plays a key role ...

Vesicle recycling in the presynaptic terminal at one end of a neuron, showing the role of dynamin during the last step of endocytosis (membrane retrieval), where the protein cuts off the vesicle from ...

Nervous system functions, from motion to perception to cognition, depend on the active zones of neural circuit connections (synapses) sending out the right amount of their chemical signals at the ...

Fruit flies are excellent research models, in part because it is so easy and inexpensive to raise them, and also because they are so well characterized. The DNA of these insects is estimated to be ...